III. Medizinische Klinik (Hämatologie und Onkologie)



Arbeitsgruppe „Inflammatory signalling in alloimmunity and infection“

Prinicipal Investigator:

PD Dr. Hendrik Poeck and Dr. Tobias Haas

III. Medizinische Klinik (Direktor: Prof. Dr. Christian Peschel)
Technische Universität München
Klinikum rechts der Isar
Phone:     +49 89 4140 4111
Fax:         +49 89 4140 4825

E-Mail:    hendrik.poeck(at)lrz.tum.de and tobias.haas(at)lrz.tum.de


Lab Members

  • Alexander Wintges (Dipl. troph. (TU München)), Ph.D. Student
  • Sarah Bek (BSc Uni Salzburg, MSc Uni Ulm) Ph.D. Student
  • Dr. Sylvia Spoerl (TU München), MD, Postdoc
  • Dr. Simon Heidegger (TU München), MD, Postdoc
  • Julius Fischer (cand. med. TU München), Promotionsprogramm „Translationale Medizin“, TUM-GS
  • Diana Kreppl (cand. med. TU München), Promotionsprogramm „Translationale Medizin“, TUM-GS
  • Vera Otten (cand. med. TU München), Promotionsprogramm „Translationale Medizin“, TUM-GS
  • Martina Schmickl (Dipl. hum. biol.), Research Assistant

Former lab Members


  • Dr. med. Michael Bscheider, MD, Postdoc (Now: Postdoc at Stanford University)
  • Chia-Ching Lin, Ph.D (Institue of Virology, Universitätsklinikum Freiburg), Postdoc

Current research interest


Work in our lab is focused on the interplay between innate and adaptive immunity in infectious and malignant diseases. Concepts of innate immune instruction of adaptive T-cell responses, initially identified as cornerstones in pathogen defence, are increasingly beeing applied to the field of cancer biology. Earlier, we were able to contribute to the fields of innate immunity and immunotherapy with regard to (i) inflammasome biology, (ii) RIG-I-like helicase (RLH) biology and (iii) Toll-like receptor activation and signaling, Recently, we identified a NLRP3-inflammasome and IL-1 beta dependent mechanism for allogeneic Th17 differentiation that may contribute to the development of acute GVHD. Our current projects are centered around the following topics:

  • Inflammasome dependent allogeneic T-cell skewing in GvHD 
  • Intestinal microbiota as determinants of GvHD/GvL, Colitis, EAE
  • Instruction of specific T-cell responses by different Pattern recognition receptors (RLHs, Inflammasomes)
  • Immunogenic cell death induced by PRR ligands and anticancer agents as innate trigger of adaptive immune responses
  • Impact of medical immune suppression on mucosal / systemic immune responses

Applications

Written applications including CV and the names of 2 professional referees are welcome and should be forwarded by email to Dr. Hendrik Poeck or Dr. Tobias Haas.

Funding

German research foundation (DFG)
Else-Kröner Fresenius-Stiftung (EKFS)
Promotionsprogramm „Translationale Medizin“ of the TU München

Selected Publications


1. Jankovic D, Ganesan, Bscheider M, Stickel N, Weber F, Guarda G, Follo M, Pfeifer D, Tardivel A, Ludigs K, Bouazzaoui A, Kerl K, Fischer J, Schmitt-Gräff A, Manoharan A, Müller L, Finke J, Martin S, Gorka O, Haas T, Peschel C, Ruland J, Idzko M, Duyster J, Holler E, French LE, Poeck H*, Contassot E*, Zeiser R* 
The Nlrp3-inflammasome regulates acute graft-versus-host disease
J Exp Med. 2013 Sep 23;210(10):1899-910
*H.P., E.C. and R.Z. contributed equally

2. Haas T, Poeck H
Apoptosis Induction by Cytosolic RNA Helicases.
J Med Microb Diagn 2:117. (2012)
doi:10.4172/2161-0703.1000117

3. Dann A*, Poeck H*, Maihofer C, Endres S, Kalinke U, Knobeloch KP, Akira S, Waisman A, Hartmann G  and  Prinz M
Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS
Nature Neuroscience 2011, Dec 4;15(1):98-106 (Impact factor 14.9)
* These authors contributed equally

4. Poeck H, Ruland J
From Virus to Inflammation: Mechanisms of RIG-I-induced IL-1beta production
Eur J Cell Biol. 2012 Jan;91(1):59-64. Epub 2011 Apr 9 (Impact factor 3.3)

5. Poeck H, Ruland J
SYK kinase signaling and the NLRP3 inflammasome in antifungal
immunity
J Mol Med. 2010 Aug;88(8):745-52 (Impact factor 4.4)

6. Poeck H*, Bscheider M*, Gross O*, Roth S, Finger K, Hannesschläger N, Schlee M, Rebsamen M, Rothenfusser S, Barchet W, Akira S, Inoue S, Endres S, Peschel C, Hartmann G*, Hornung V* and Ruland J*
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1beta production
Nature Immunology 2010 Jan;11(1):63-9 (Impact factor 25.1)
*These authors contributed equally

7. Gross O*, Poeck H*, Bscheider M, Dostert C, Hannesschläger N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J
Syk kinase signaling couples to the Nlrp3 inflammasome for anti-fungal host defence
Nature. 2009 May 21;459(7245):433-6 (Impact Factor 28.8)
*These authors contributed equally

8. Besch R*, Poeck H* , Hohenauer T, Senft D, Häcker G, Berking C, Hornung V, Endres S, Ruzicka T, Rothenfusser S, Hartmann G
Proapoptotic signalling by RIG-I and MDA-5 results in type I interferon independent apoptosis in melanoma
J Clin Invest. 2009, Aug; 119(8):2399-411 (Impact Factor 16.6)
*These authors contributed equally

9. Poeck H*, Besch R*, Maihoefer C, Renn M, Tormo D, Morskaya S, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Häcker G, Neuenhahn M, Busch D,  Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, Tüting T & Hartmann G
5’-triphosphate siRNA: turning gene-silencing and RIG-I activation against melanoma
Nat Med. 2008 Nov;14 (11):1256-63 (Impact Factor 27.6)
*These authors contributed equally

10. Haas T, Schmitz F, Heit A, Wagner H.
Sequence independent interferon-alpha induction by multimerized phosphodiester DNA depends on spatial regulation of Toll-like receptor-9 activation in plasmacytoid dendritic cells. Immunology. 2009 Feb;126(2):290-8

11. Haas T, Metzger J, Schmitz F, Heit A, Müller T, Latz E, Wagner H.
The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation.
Immunity. 2008 Mar;28(3):315-23 (Impact Factor 28.8).



PD Dr. H. Poeck

Dr. T. Haas



2010 · III. Medizinische Klinik (Hämatologie / Onkologie) am Klinikum rechts der Isar der Technischen Universität München